Objective: To observe the clnical effects of Sha Shen Mai Dong Tang on alleviating toxic and side reaction of iressa in the treatment of advanced non-small cell lung cancer.Method: 80 cases with advanced non-small cell lung cancer were randomly divided into the trearment group and control group,Patients in the trearment group received both iressa(150mg qd [...]
18
May
18
May
The Expression and Correlation Studies of HPV16/18 Infection and p53 in Female with Breast Infiltrating Ductal Carcinoma
Objective To explore the expression and their relationship of HPV16/18 infection and p53 in female with breast infiltrating ductal carcinoma.Methods The expression level of HPV16/18 DNA and p53 in women breast infiltrating ductal carcinoma(n=45),breast fibroadenoma(n=20) and normal breast tissue(n=20) were detected with immunohistochemistry methods and PCR technology,respectively.Results HPV16/18 DNA and p53 protein expression rate in [...]
17
May
Using ultracision and LigaSure in laporoscopic radical surgery for low rectal cancer
Objective To explore the value of ultracision and LigaSure in laparoscopic radical surgery for low rectal cancer.Methods Sixty-one cases with low rectal cancer underwent laparoscopic resection using ultracision and LigaSure including 40 cases of rectal anterior resection and 21 cases of abdominal perineal resection(Miles operation).Results Laparoscopic resection was performed successfully in all patients without conversion [...]
17
May
Evaluation on the quality of life of prostatic cancer patients after radical prostatectomy and its influencing factors
Objective:To investigate the quality of life of prostatic cancer patients after radical prostatectomy and its influencing factors.Methods:The questionnaire was used to make an investigation survey on 100 patients after radical prostatectomy and the general quality of life of the patients was evaluated respectively in one week before surgery,one month and 3 to 6 months after [...]
17
May
Effect of Uv-c irradiation on expression and distribution of PTEN in cell line MCF-7
Objectives To study the expression and distribution of PTEN in breast cancer cell MCF-7 after Uv-c irradiation.Methods The cell cycle distribution was examined using flow cytometry.The protein expression was detected with immunoblot analysis.The protein location was detected with immunofluorescence analysis.Results Before UV-c irradiation,the PTEN cells mainly distributed in the cytoplasm surrounding the nucleus;After 24 hours [...]
17
May
Analysis of neoadjuvant intra-atrerical chemotherapy for locally advanced cervical cancer
Objective To study the curative effects and feasibility of intra uterine arterial neoadjuvant chemotherapy in patients for locally advanced cervical cancer.Methods A retrospective study of 116 patients with FIGO stage Ⅱa～Ⅱb cervical cancer were performed intra-arterial neoadjuvant chemotherapy during the period of September 2005 and June 2008 in Affiliated Tumour Hospital,Xinjiang Medical University,after 2～3 weeks,86 [...]
17
May
The comparative analysis of neoadjuvant chemotherapy by two ways for locally advanced cervical cancer
Objective To compare the therapeutical effect of venous and uterine arterial neoadjuvant chemotherapy on stage ⅠB2～ⅡB locally advanced cervical cancer,in order to direct the healing of clinic.Methods A retrospective study was carried out on 142 patients with FIGO stage ⅠB2～ⅡB locally advanced cervical cancer admitted to our hospital from Feb 2008 to Sept 2009.These patients [...]
17
May
Expression of two transcriptional splice variants CK1αLS and CK1αS of human CSNK1A1 gene in cell lines
Aim:To detect the functions of casein kinase 1alpha 1(CSNK1A1 or CK1α)gene on carcinogenesis and development by studying the expression of two transcriptional splice variants CK1αLS and CK1αS of CK1α gene in normal cell lines and malignant cell lines.Methods: The mRNA expression levels of CK1αLS and CK1αS of CSNK1A1 gene were examined by RT-PCR in thirty-six [...]
17
May
Advances in autophagy and high-mobility group box-1 protein(HMGB1)-mediated drug-resistance of tumors
Resistance to chemical drugs and irradiation therapy,namely,drug resistance are usually induced in malignant tumors through diverse mechanisms.An important mechanism is drug-induced autophagy.High-mobility group box-1 protein 1(HMGB1) is a highly conserved non-histone and DNA-binding protein that plays a key role in chromatin construction,gene transcription,recombination,DNA damage repair and cell death/survival etc.These functions of HMGB1 are related to [...]
17
May
Adaptor protein Crk Ⅰ mediates malignant potential of human ovarian cancer
Objective To explore the role of adaptor protein CrkⅠ in malignant potential of human ovarian cancer.Methods Crk and Dock180 expression were detected by Western blotting in ovarian cancer tissues(EOC,n=28),benign ovarian tumors(BOT,n=13) and normal ovary tissues(Normal,n=10).Co-precipitation was performed to evaluate the in vivo protein-protein interaction of Dock180 and Crk in 3 different ovarian cancer cell lines(SKOV3,MCAS [...]