Dendrimers can target tumor taking advantage of enhanced permeation and retention effect(EPR).In this study,partially acetylated generation 5(G5) polyamidoamine(PAMAM) dendrimer was conjugated with the active targeting moiety(avidin).The nanoparticles which have passive and active tumor-targeting were radiolabel with 99mTc.The nano-particle conjugated with avidin(avidin-G5-1B4M-99mTc) exhibited much higher cellular uptake into Hela cells than those without avidin conjugate.Using this [...]
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May
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May
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May
Effects of NDRG1 on proliferation,invasion and migration of human colorectal cancer cell line HT-29
Objective To investigate the effects of NDRG1 on proliferation,invasion and migration of human colorectal cancer cell line HT-29 in vitro.Methods LipofectamineTM 2000 was used to transfect NDRG1 into human colorectal cancer HT-29 cells.The expression level of NDRG1 was measured by fluorescence microscopy and immunocytochemical staining.The cell cycle distribution was determined by fluorescence-activated cell sorting(FACS).The ability [...]
18
May
Clinical analysis of conservative treatment with progestin in young women with endometrial carcinoma
OBJECTIVE:To investigate the efficacy,security,pregnant rate,recurrence rate of conservative treatment with progestin in young women with early-stage well differentiated endometrial cancer.METHODS:The medical records of young patients with endometrioid endometrial adenocarcinoma,who were treated with progestin from January 01,2001 to December 31,2008 were retrospectively analyzed.RESULTS:Three patients were treated with LH+BSO 3 months after progestin treatment complete remission was [...]
18
May
Expression and its Clinical Significance of P53,CD44 and EGFR in Non-small Cell Lung Cancer
Objective To observe the expression and its clinical significance of P53,CD44 and EGFR in non-small cell lung cancer(NSCLC).Methods Expression of P53,CD44 and EGFR was detected by immunohistochemistry in 87 NSCLC tissues,and their relationship was analyzed.Results The positive rate of P53,CD44 and EGFR was 49.4%,60.9% and 67.8%,respectively,in NSCLC tissues.The positive rate of P53 with stage III-IV [...]
17
May
Clinical observation of Astragalus and conformal radiotherapy combined chemotherapy in treatment of cervical cancer
Objective To explore the effect of Astragalus and conformal radiotherapy combined with chemotherapy on locally advanced cervical cancer.Methods Totally 40 cervical cancer patients were randomly divided into two group.The 20 cases in the Astragalus group and the 20 cases in the control group.The blood parameters of white blood cells,B cells and NK cell levels,the recent [...]
17
May
The Development Investigation and Application of the History Case Data for the Large Bowel Carcinoma
Objective To investigate and develop a special data base software for the large bowel carcinoma and to realize the disposal,sharing and communication for the large bowel carcinoma it shall form the base of information service system for clinical and research. Methods To use the NET as the operation system, and combine Microsoft SQL Server as [...]
17
May
The clinical analysis of anal function after low or ultralow rectal anastomosis in patients with rectal cancer
Aim:To investigate the feasibility of low/ ultralow rectal cancer anastomosis to reserve Anal Function.Methods: Experiment group was composed of thirty-two patients with low or utralow rectal cancer.Controlled group was composed of twenty-five patients with rectal cancer.Both group were operated with total mesorectal excision(TME) to sever mesorectum,stapler technique was used to anastomose the incision,inspect Anal Function [...]
17
May
Cancer systems biology:signal processing for cancer research
In this editorial we introduce the research paradigms of signal processing in the era of systems biology.Signal processing is a field of science traditionally focused on modeling electronic and communications systems,but recently it has turned to biological applications with astounding results.The essence of signal processing is to describe the natural world by mathematical models and [...]
17
May
Application value of core needle biopsy in diagnosing breast cancer
Objective:To explore application value of core needle biopsy(CNB) in diagnosing breast cancer.Methods:297 patients with highly suspicious breast masses were performed hollow needle aspiration biopsy in which the result were contrastively analysed on the histopathology between puncture biopsy and surgical specimens.Results:There were 23 cases of benign masses including 8 cases in fibroadenoma and 15 cases in [...]