Objective:To study the relationship of CHFR CpG island methylation status on proliferation and apoptosis of esophageal cancer Eca109 cells.Methods: Eca109 cells were treated with different concentrations(2,5,and 10 μmol/L) of 5-Aza-2′-deoxycytidine(5-Aza-CdR),and untreated Eca109 cells were used as control.Methylation-specific PCR(MSP) analysis was used to evaluate the CpG island methylation status of CHFR gene,and RT-PCR was used to [...]
18
May
18
May
Comparison of Anti-leukemia Activity among Different Polar Parts of Galium aparine L. Extracts
[Objective] To compare effects of different polar parts of Galium aparine L.extracts on anti-leukemia activity.[Method] Galium aparine L.was refluxed with 95% ethanol and the obtained extracts were separated into different polar parts by Soxhlet extractor.The relationship between polar parts and biological activity was investigated through leukemia cells-K562 in vitro antitumor activity test.[Result] The content of [...]
18
May
Evaluation of Batch Effects of Genome Wide Microarrays from the TCGA Database
Genome-wide methylation microarrays were widely used in cancer research.However,recent research suggested batch effects in high throughput data were often overlooked and lead to incorrect conclusions.The Cancer Genome Atlas(TCGA) database contained many methylation array datasets which were preformed on different batches.Here,we analyzed datasets from 7 cancer types in TCGA database.We found batch effects were widespread for [...]
18
May
Clinical characters and etiology of patients with precordial low voltage
Objective We retrospectived clinical characters of patients with precordial low voltage.Methods clinical features,diagnosis and CT,X-ray were analyzed in 91 patients with precordial low voltage.Results 51 patients were suffered from cancer,account for 51.6%,breast cancer and lung cancer were 14.3%,12.1% respectively,followed by myocardial infarction and ovarial cancer,caesarean section ranked fourth.Conclusion cancer may be the main cause of [...]
18
May
Clinical Treatment Progress of Traditional Chinese Medicine in Chemotherapy-induced Nausea and Vomiting
Nausea and vomiting are the most common symptoms of side effect encountered in chemotherapy.In light of traditional Chinese medicine theory,the basic pathogenesis of the chemotherapy-induced nausea and vomiting(CINV) is considered to be splenic asthenia and dampness encumbrance,qi asthenia and phlegm stagnation and adverse rising of gastric qi.Treatments of invigorating spleen to remove phlegm and benefit [...]
17
May
Analysis of acute kidney injury of primary liver cancer after TACE
Objective: To study the cause of acute kidney injury of primary liver cancer after TACE.Methods: Multivariate analysis of data of 286 patients with primary liver cancer who were treated by TACE.Results: Of 286 patients,23 patients had acute kidney injury after TACE.There was a closely correlation between acute kidney injury and age and basis diseases and [...]
17
May
Gastroscopic and pathological characteristics of patients with or without schistosomiasis in Poyang Lake area
Objectives To understand the gastroscopic and pathological characteristics of patients with or without schistosomiasis in Poyang Lake area,and to explore the relationship between schistosomiasis and pathological changes of gastric mucosa.Methods Volunteers with or without schistosomiasis were recruited and divided into a case group and a control group.All the objects were examined by electronic gastroscopy and [...]
17
May
Expression of CDX2 in Gastric Carcinoma and Its Relation to H.pylori Infection.
Objective To investigate the expression of Caudal-type Homeobox Protein 2(CDX2) in various gastric diseases and the function of gastric carcinogenesis and differentiation;and study the influence of H.pylori infection on it.Methods Three hurdrend cases of gastric mucosa selected randomly were detected by immunohistochemistry.Results In chronic atrophic gastritis and gastric cancer,CDX2 expressed higher than that in superficial [...]
17
May
THE CLINICAL RESEARCH OF SUBMENTAL MYOCUTANEOUS FLAP FOR REPAIRING BUCCAL DEFECTS AFTER CANER ABLITION
Objective To explore the clinical application of submental myocutaneous island flap in repairing buccal defects after caner ablition.Methods Clinical data of 11caes,buccal defects were repaired with facial atery -submental artery island myocutaneous flap,among them,7 patients were males and 4 were females;the ages of the patients ranged from 39 to 85 years(62 years on average),two patients [...]
17
May
Clinical research of improved modality about L3 axillary lymph node dissection in breast cancer
Objective To identify the clinical application and significance of modified radical mastectomy about improved L3 axillary lymph node dissection in clinically apparent axillary lymph nodes of patients with breast cancer.Methods One hundred and fifty four patients with clinically apparent axillary lymph nodes were collected,clinically stage groupings: Ⅱa 58 cases,Ⅱb 75 cases,Ⅲ 21 cases,they were operated [...]