OBJECTIVE:To evaluate the anti-angiogenic and anti-tumor effects of low-dose paclitaxel combined with(-)-epigallocatechin-3-gallate(EGCG) on gastric cancer.METHODS:Nude mice bearing BGC-823 human gastric carcinoma were randomized into five groups.The nude mice were administered by sterile saline(0.9%),maximum tolerable dose(MTD) paclitaxel,low-dose paclitaxel,EGCG and low-dose paclitaxel combined with EGCG,respectively.Tumor growth was monitored in each group.Expression of microvessel density(MVD) and VEGF was [...]
18
May
17
May
14
May
Clinical Significance and Expression of Salivary Vascular Endothelial Growth Factor in Patients with Oral Squamous Cell Carcinoma
Objective:To investigate the relationship between the VEGF level in saliva and the clinical and histopathological features of oral squamous cell carcinoma.Methods:The salivary level of vascular endothelial growth factor(VEGF) in patients with oral squamous cell carcinoma was measured by means of enzyme linked immunosorbent assay in 75 patients with oral squamous cell carcinoma(OSCC).VEGF level of 30 [...]
13
May
Expression and value of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue
Objective To study the expression of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue,and explore the relationship between the expression of Ang-1,Ang-2 and receptor Tie-2 with the histological differentiation degree,provide new targets for the clinical treatment of colorectal cancer.Method The expression of Ang-1,Ang-2 and receptor Tie-2 in 64 cases of colorectal cancer tissues were detected [...]
12
May
(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer
AIM: To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer. METHODS: Human gastric cancer (AGS) cells were treated with IL-6 (50 ng/mL) and EGCG at different concentrations. VEGF, total Stat3 and activated [...]
12
May
MiR-148a inhibits angiogenesis by targeting ERBB3
MicroRNAs (miRNAs) play an important role in carcinogenesis in various solid cancers including breast can-cer. Down-regulation of microRNA-148a (miR-148a) has been reported in certain cancer types. However, the biological role of miR-148a and its related targets in breast cancer are unknown yet. In this study, we showed that the level of miR-148a was lower in [...]
12
May
Effects of survivin siRNA on angiogenesis of human breast cancer xenografts in nude mice
Objective To investigate the effects of survivin siRNA on angiogenesis of human breast cancer MCF-7 cell xenografts in nude mice.Methods The animal model of tumor xenograft was established by transplantation with MCF-7 cells into nude mice.The models were randomly assigned to 3 groups: PcDNA3-Survivin siRNA treatment,PcDNA treatment and control group,which were respectively injected with PcDNA3-siRNA [...]
12
May
Clinical Significance of Ephrin A1 Expression in Cervical Carcinoma
Objective: To study the expression of Ephrin A1 in cervical cancer and it relationship with hypoxia microenvironment and angiogenesis.Methods: Immunohistochemistry staining method(SP method) was used to evaluate the expression of Ephrin A1 and Eph A1 receptors,and HIF-1α,and microvessel density(MVD) in different cervical tissues(65 cases of cervical carcinoma,73 cases of cervical intraepithelial neoplasia and 49 cases [...]
11
May
Clinical Significance of Ephrin A1 Expression in Cervical Carcinoma
Objective: To study the expression of Ephrin A1 in cervical cancer and it relationship with hypoxia microenvironment and angiogenesis.Methods: Immunohistochemistry staining method(SP method) was used to evaluate the expression of Ephrin A1 and Eph A1 receptors,and HIF-1α,and microvessel density(MVD) in different cervical tissues(65 cases of cervical carcinoma,73 cases of cervical intraepithelial neoplasia and 49 cases [...]
10
May
Effect of Jianpi Jiedu Recipe on Microvessel Density and Cyclooxygenase-2 Expression in Helicobacter pylori Induced Gastric Cancer
Objective To investigate the regulatory effect of Jianpi Jiedu Recipe (JJR) on the microvessel density (MVD) and cyclooxygenase-2 (COX-2) in long-term infection of Helicobacter pylori induced gastric cancer of C57BL/6 mice,thus providing experimental bases for its treatment of the H. pylori correlated gastropathy. Methods C57BL/6 mouse gastric cancer model induced by H. pylori infection was [...]