Objective To study the expressions of Bcl-2,Bag-1 in colon carcinoma and its relationship to clinical pathological characteristics and prognosis of colon cancer.Methods Immunohistochemistry was used to detect the expressions of Bcl-2,Bag-1 proteins in 55 cases of colon cancer tissues,33 para-cancer tissues and 15 normal colon tissues and analyze them integrated with clinical pathological features and [...]
16
May
16
May
Development of small molecule inhibitors on Bcl-2/Bcl-X_L protein
Members of the Bcl-2 family play vital roles in cell apoptosis.Overexpression of Bcl-2,Bcl-XL or both Bcl-2 and Bcl-XL proteins is one of the most important reasons for tumorigenesis and drug resistance,thus indicating that the research on small-molecule inhibitors for antiapoptotic Bcl-2 proteins may be a promising area in the development of cancer therapeutics.This review great [...]
15
May
Expression and significance of E-cadherin and Bcl-2 in early renal carcinoma and adjacent tissues of different levels of distance
Objective To test the expression of E-candherin and Bcl-2 in early renal carcinoma and adjacent tissues,provide a theoretical basis for the safety margins in nephron sparing surgery.MethodsThe clinical data of 45 patients who were undertaken radical nephrectomy in the First Affiliated Hospital of Henan Scientific and Technological University,pathological diagnosis were all renal clear cell carcinoma.Taken [...]
14
May
Effects of Yanhuanglian Total Alkalions on Bcl-2 Activity of Oral Squamous Carcinoma Cell Lines
Objective: To study the effect of yanhuanglian total alkalions(YHL-TA) on the expression of Bcl-2 in human tongue squamous cancer cell line Tca8113 Methods: PCR and Western-blotting were used to detect the expression variations of Bcl-2 in Tca8113 cells.Results: YHL-TA inhibited the expression intensity of Bcl-2 in a time-and dose-dependent manner.YHL-TA could induce the apoptosis of [...]
12
May
Influence of p53 and Bcl-2 Expression of Anti-Cancer Bioactive Peptide on Experimental Gastric Cancer
Objective To investigate the expression difference of apoptotic related gene p53 and Bcl-2 of anti cancer bioactive peptide(ACBP) treated tumor-loaded nude mice and the potential anti cancer mechanism of ACBP.Methods Nude mice were divided into 2 groups randomly: 10 as control group and 10 as experimental group.2 groups of nude mice were administered with 0.4 [...]
11
May
BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation
BRCA1 has been proposed to be tightly linked to the resistance of tumor cells to ionizing radiation. The pathway leading to this phenomenon is not yet clear. In this work, we investigated the role of BRCA1 in the apoptosis regulation in response to carbon ion irradiation. We utilized three different cancer cell lines with various [...]
11
May
Expressions of Connexin 43 mRNA,Bcl-2 mRNA,and Bax mRNA in Bladder Transitional Cell Carcinoma
Objective To investigate the expressions of connexin43,Bcl-2,and Bax mRNA in bladder transitional cell carcinoma(BTCC). Methods The expressions of connexin43(Cx43),Bcl-2,and Bax mRNA were detected by semi-quantitative RT-PCR in 35 cases of BTCC and 21 cases of para-carcinoma tissue,with 15 cases of normal bladder tissues as controls.The correlation among the expressions of connexin43,Bcl-2,and Bax mRNA were explored,and [...]
11
May
Induction of Apoptosis in Malignant Melanoma Cells by LDE and its Mechanisms
Objective To study the effect of action of LD extract(LDE)on the growth of malignant melanoma cells and its mechanisms.Methods The effects of LDE on the growth of the melanoma tumor cell line B16 was evaluated by MTT.The LDE-induced apoptosis of the cancer cells was detected by labeling with fluorescence probe.The apoptotic morphological changes were observed [...]
10
May
The effect of Allicin combined with Sorafenib on proliferation of human liver cancer cell line HepG2 and mechanism
Objective:To investigate the inhibitory effect of Allicin combined with Sorafenib on proliferation and the effect on the Bcl-2 gene mRNA level of human liver cancer cell line HepG2 in vitro.Methods:Cell proliferation was evaluated by Methyl thiazolyl tetrazolium(MTT) assay.Bcl-2 gene mRNA level was examined by RT-PCR method.Results:Allicin combined with sorafenib reduced the ratio of the proliferation [...]
9
May
Expression and clinical significances of BCL-2 and P53 in non-small cell lung cancer
Objective To investigate the expression and its significance of P53 and BCL-2 in non-small cell lung cancer(NSCLC).Methods The expression of P53 and BCL-2 was evaluated in 60 specimens of NSCLC and 10 specimens benign lung tissues by immunohistochemistry S-P method.Results The positive rate of BCL-2 in NSCLC was(51.7%),which was significantly higher than that of BCL-2 [...]