Objective Explore the breast augmentation treat breast cancer treatment and curative effcet.Methods 492 cases of bresat cancer patients were done to protect breast augmentation(Breast group),590 cases of breast cancer patients mastectomy were compared(Compared group).Results On the average,the breast group is better than the compared group at the average operative time,perioperative bleeding and surgical complication rate.Two [...]
18
May
18
May
The expression and significance of thyroid hormone in nonmaglinant-maglinant breast diseases
Objective:To observe the expression and significance of thyroid hormone in nonmaglinant-maglinant breast disease.Methods:The expression of thyroid hormone(T3,FT3,T4,FT4) was assayed by electrochemiluminescence in breast cancer,breast fibroadenoma,breast hyperplasia and normal subjects.Results:The expression of T3,T4 and FT4 is nonsense between breast cancer,breast fibroadenoma,breast hyperplasia and normal subject(P>0.05).The expression of FT3 is significantly different(P<0.001),expression of FT3 is significantly higher [...]
18
May
The study of correlation Single nucleotide polymorphismof Notch1 signal molecule in the breast cancer and hyperplasia lesions
Objective: To explore the relevance between the Single nucleotide polymorphism of the Notch1 geners 3124591 and breast invasive ductal carcinoma and ductal hyperplasia lesions.Methods:The Single nucleotide polymor-phism of Notch1 gene rs3124591 in human breast invasive ductal carcinoma(IDC,n=100),ductal carcinoma in situ(DCIS,n=50),usual ductal hyperplasia(UDH,n=100) and controls(BH,n=100) were quantitative detection byMALDI-TOF MS.Results:Our results showed that the mean The [...]
17
May
Study on Mechanism of Low Expression of Tumor Suppressor Gene DLC-1 in Human Breast Cancer Cell Line
Objective:To investigate the mechanism of low expression of tumor suppressor gene dlc-1 in human breast cancer cell line.Methods:Methylation-specific PCP(MSP) was used to examine the methylation status of DLC-1 promoter.MCF-7 cells were treated by different concentrations of 5-Aza-CdR.DLC-1 mRNA levels were examined by RT-PCR and Real-time PCR before and after treatment with 5-Aza-CdR.Results:There was methylation in [...]
17
May
p21ras Expression in Endometrium of Postmenopausal Breast Cancer Patients Treated with Tamoxifen.
Objective To investigate the expression of p21ras in endometrium of postmenopausal women taking tamoxifen(TAM) for breast cancer,and study the relationship between ras mutation and tamoxifen-related endometrial lesion.Methods A prospective study was performed in 85 cases of breast cancer patients who had operation in the 2nd Affiliated Hospital of Wenzhou medical college from January 2005 to [...]
17
May
Clinical research of improved modality about L3 axillary lymph node dissection in breast cancer
Objective To identify the clinical application and significance of modified radical mastectomy about improved L3 axillary lymph node dissection in clinically apparent axillary lymph nodes of patients with breast cancer.Methods One hundred and fifty four patients with clinically apparent axillary lymph nodes were collected,clinically stage groupings: Ⅱa 58 cases,Ⅱb 75 cases,Ⅲ 21 cases,they were operated [...]
17
May
Correlation of microRNA-21 expression with TGF-β1 in breast cancer
Aim:To investigate the expression of microRNA-21(miR-21)and transforming growth facor-β1(TGF-β1) and to explore their relationship in breast cancer.Methods: MCF-7 was treated with different concentrations of TGF-β1(0、1.25、2.5、5、10 ng/ mL)for 24 h or treated with 10ng/ml TGF-β1 at different time(0、6、12、24、48、72 h),the expression of miR-21 was detected by stem-loop real-time PCR.In thirty-seven breast cancer cases,to explore the relationship of [...]
17
May
Application value of core needle biopsy in diagnosing breast cancer
Objective:To explore application value of core needle biopsy(CNB) in diagnosing breast cancer.Methods:297 patients with highly suspicious breast masses were performed hollow needle aspiration biopsy in which the result were contrastively analysed on the histopathology between puncture biopsy and surgical specimens.Results:There were 23 cases of benign masses including 8 cases in fibroadenoma and 15 cases in [...]
17
May
Correlation of Cyclin A1 Gene Hypermethylation in Promoter Region and Metastasis of Breast Carcinoma
Objective:To investigate the methylation pattern of CCNA1 in breast carcinoma and explore the role of these epige-netic changes in tumorgenensis.Methods:95 specimens of breast cancer were used,and the DNA was extracted by Qiagen procedure.Methylation change in the promoter region of CCNA1 was determined by using restricted enzyme cut-PCR.Results:The positive rate of gene promoter hypermethylation of CCNA1 [...]
17
May
Local microwave hyperthermia and chemotherapy used in efficacy of chest wall recurrence of breast cancer
Objective To evaluate the local microwave hyperthermia and chemotherapy used in chest wall recurrence of breast cancer.Methods Among 43 patients with chest wall recurrence of breast cancer,there are 22 patients treated with chemotherapy combined with local microwave hyperthermia and 21 patients treated with simple chemotherapy.Two groups of patients with characteristics exists significant difference(P>0.05).Results The results [...]