Objective To determine the effect of tubeimoside 1(TBMS1) in enhancing chemosensitivity of drug-resistant ovarian cancer cell line(A2780/DDP) to cisplatin.MethodsThe A2780/DDP cells were treated with different concentrations of cisplatin and TBMS1 to analyze 50% inhibiting concentration(IC50) by methyl thiazolyl tetrazolium(MTT) assay.Experiment was divided into 4 groups.Control group:treatment with physiological saline;cisplatin group:treatment with 6 μmol/L cisplatin;Combination of [...]
17
May
17
May
Efficacy of Three Chemotherapy Regimens for Advanced Esophageal Cancers
Objective To evaluate therapeutic efficiency,safety of paclitaxel(PTX)/nedaplatin(NDP) and paclitaxel(PTX)/cisplatin(DDP) therapy for patients with advanced esophageal cancers.Methods One hundred and thirty five patients with advanced esophageal cancers were analyzed.Group PTX+NDP:composed 44 cases,patients in PTX/NDP group were given PTX 150 mg/m2 on d1 and NDP 20 mg/m2 from d2 to d5.Group PTX+DDP:composed 46 cases,patients in PTX/DDP group [...]
17
May
Clinical observation of irinotecan combined with cisplatin in the treatment of advanced gastric cancer
Objective To evaluate the efficacy and adverse effects of irinotecan(CPT-11) combined with cisplatin(DDP) in the treatment of patients with advanced gastric cancer.Methods Thirty-two cases of initial treatment and retreatment with advanced gastric cancer received chemotherapy.Irinotican was administered at 150-170mg/m2 by 90 min infusion on d1.Cisplatin was administered at 25mg/m2 by infusion on d1-d3.Every 21 days [...]
17
May
Clinical study of recombinant human endostatin(endostar) combined with platinum agents in the treatment of malignant pericardial cavity effusion
Objective To observe the efficacy and safety of recombinant human endostation injection(endostar),a new molecular targeted antitumor agent,alone or combine with the chemotherapy platinum agents(cisplatin or carboplatin) for pericardial cavity infusion therapy on the malignant pericardial cavity effusion.Methods Six patients were diagnosed with serious malignant pericardial cavity effusion(5 cases with non-small cell lung cancer and 1 [...]
16
May
A study of cisplatin plus docetaxel or gemcitabine in treating advanced non-small cell lung cancer
Objective: To compare the efficacy and adverse reactions between DC and GC regimens in the treatment of advanced non-small cell lung cancer(NSCLC).Methods: 84 cases with advanced NSCLC were randomized devided into two groups,42 cases received the DC regimen chemotherapy and 42 cases received the GC regimen chemotherapy.The efficacy and adverse reactions were evaluated after two [...]
16
May
Therapeutic effect of combined cisplatin and docetaxel vs fluorouracil regimen with concurrent radiotherapy on advanced esophageal carcinoma
Objective To compare the therapeutic effect and adverse effects of two regimens,namely cisplatin and docetaxel(DC) regimen and fluorouracil(PF) regimen,both with concurrent radiotherapy,in the treatment of advanced esophageal squamous cancer.Methods Forty-eight patients with esophageal squamous cancer were randomly assigned in DC regimen and PF regimen groups.All the patients received conventional radiotherapy at a total dose of [...]
16
May
RNA Interference Targeting GRP75 Decreases Cisplatin Resistance in Human Lung Adenocarcinoma Cell
Background and objective GRP75,a member of HSPs which is overexpressed in some resistant cancer cells,is a molecular chaperone mainly located in mitochondrial membrane. The aim of this study is to investigate the role of GRP75 on the resistant mechanisms of cancer cells by downregulating GRP75 expreesion via RNAi approach. Methods Cis-platin-resistant cell A549/CDDP was established [...]
15
May
Pemetrexed combined with cisplatin for second-line therapy of advanced non-small cell lung cancer
Objective To investigate efficacy and untoward effect of pemetrexed combined with cisplatin(PC Program) for second-line therapy of advanced non-small cell lung cancer(NSCLC).Methods 19 patients with advanced NSCLC who had received first-line therapy but had relapsed or progressed were given 500 mg/m2 of pemetrexed and 75mg/m2 of cisplatin,and 21 days were considered as one cycle,then evaluated [...]
15
May
Recombinant human endostatin combined with topotecan plus cisplatin regimen for advanced small-cell lung cancer
Objective To analyze the tolerance and short-term effect of recombinant human endostatin combined with topotecan plus cisplatin(TP) regimen on patients with advanced small-cell lung cancer.Methods Eighty-nine patients with advanced small-cell lung cancer were enrolled and divided into observation group(n=45) and control group(n=40).The patients in control group received TP regimen for 2 cycles while those in [...]
15
May
Enhancement of human lung cancer cell sensitivity to chemotherapy by JAB1 over-expression
Objective To search for the methods to increase the sensitivity of tumor cells to chemotherapy in anoxic zone of lung cancer and finally to reverse chemotherapeutic resistance of lung cancer by discussing the increasing of sensitivity of human lung cancer cell(A549) to chemotherapy through over-expression of JAB1 induced by hypoxia-inducible factor 1(HRE-1) promoter.Methods An eukaryotic [...]