Objective:To study the association between the prevalence of diabetics mellitus(DM) and colorectal incidence(CRC).Methods: The data of the prevalence of DM and incidence of CRC in 170 countries were collected and correlation relation was analyzed between DM and CRC.Results: The prevalence of DM was positively associated with the incidence of CRC.The spearman’s coefficients of correlation(rs) in [...]
18
May
18
May
Study of the Methods of Fluorescence in Situ Hybridization and Immunohi stochemistry in Detecting HER-2 in Colorectal Cancer
Objective:To detect HER-2 expression in colorectal cancer tissues using immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH),to analyze the significance of HER-2 expression in colorectal cancer. Methods:The expression of HER-2 protein in 68 cases of colorectal cancer and 40 cases of peri-cancer mucosa was detected by EnVision IHC.The correlations of HER-2 expression with clinicopathological parameters and prognosis [...]
17
May
A Clinical Analysis of Surgical Treatment for 56 Elderly Patients with Colorectal Cancer
Objective To explore the clinical characteristics,surgical treatment,perioperative management,and prevention of postoperative complications for the elderly patients with colorectal cancer so as to improve surgical curative effects.Methods The clinical data of 56 elderly patients with colorectal cancer from January 2008 to December 2010 were analyzed retrospectively.Results All the patients were treated surgically.56 patients were followed for [...]
17
May
17
May
17
May
P53 AND ERK GENE EXPRESSION IN COLONIC CARCINOMA
Objective:To investigate the expression of p53 and ERK in colonic carcinoma(CC) and their relationship tocliniocpathological factors.Methods:In 40 cases with CC,by using immunoihstochemicla technigue,the expression of p53 and ERK was detected.Results:1.The positive rate of P53 in colorectal cancer was 57.5%,associating with the loss of tumor differentiation 、lymphnode metastasis、deep invasion and dukes stage((p<0.05),but not with patients sex、age、tumor [...]
17
May
A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female
Objective:To investigate the association of XRCC4 polymorphic variants at G-1394T(rs6869366) with colorectal cancer susceptibility.Methods:In this hospital-based case-control study,the association of XRCC4 polymorphism with colorectal cancer risk in Chinese population was investigated.In total,171 patients with colorectal cancer and 171 healthy individuals matched for age and gender were selected.The genomic DNAs of the patients and controls were [...]
17
May
Effects of lanthanum chloride on the proliferation and tumor-associated miRNAs’ expression in human colorectal cancer HT-29 cells
Objective To investigate the effects of lanthanum chloride on the proliferation of human colorectal cancer HT-29 cells and the expression of tumor-associated microRNAs.Methods Human colorectal cancer HT-29 cells were cultured routinely in vitro.The inhibition effects of lanthanum chloride on cell-proliferation were determined by MTT method.The effects of lanthanum chloride on the expression of microRNA let-7 [...]
17
May
Expression of transforming growth factor β receptor Ⅱ in colorectal cancer and its relationship to CyclinD1
[Objective]To study the expression of transforming growth factorβreceptor Ⅱ(TGF-βRⅡ)and CyclinD1 in colorectal adenoma and colorectal cancer,and to explore their roles in the pathogenesis of colorectal carcinoma.[Methods]The tissues from Fifty-six cases of colorectal cancers,29 cases of colorectal adenomas and 56 corresponding cancer-adjacent normal tissues were measured to test the expression of TGF-βRⅡ and CyclinD1 by immunohistochemistry [...]
17
May
Expression of E-cadherin and integrin α5β1 and their relationships with biological behavior of colorectal cancer and prognosis of patients
Objective:To investigate the expression of E-cadherin and integrin α5β1 in colorectal cancer and their relationship with tumor biological behavior and patients’ survival.Methods:Immunohistochemical staining of E-cadherin and integrin α5β1 were performed in 41 samples of colorectal carcinoma,and in normal colorectal mucosa samples obtained at 10 cm from the tumor edge as control.Results:The expression rate of E-cadherin [...]