Objective:To investigate the expression of E-cadherin and integrin α5β1 in colorectal cancer and their relationship with tumor biological behavior and patients’ survival.Methods:Immunohistochemical staining of E-cadherin and integrin α5β1 were performed in 41 samples of colorectal carcinoma,and in normal colorectal mucosa samples obtained at 10 cm from the tumor edge as control.Results:The expression rate of E-cadherin [...]
17
May
16
May
Comparative study of epithelial-mesenchymal transition in human colorectal carcinoma,its lymphatic metastasis and colon cancer cells
Background and purpose:Although there were a lot of reports about epithelial-mesenchymal transition(EMT),but the conclusion is still not exclusive.This study investigated the difference between epithelial-mesenchymal transitions in human colorectal carcinoma as well as its lymphatic metastasis and colon cancer cell lines.Methods:The expression of E-cadherin and vimentin mRNAs in human colon cancer cell lines SW480 and SW620 [...]
16
May
Expression of Ezrin,CD44V6 and E-cadherin in Tissues of Colon Carcinoma and Its Significance
Objective To investigate the expression of Ezrin,CD44V6 and E-cadherin in tissues of colon carcinoma and its significance.Methods Immunohistochemistry(IHC) method(SP method)was used to examine the expression of Ezrin,CD44V6 and E-cadherin in 78 cases colon carcinoma,30 cases colorectal adenomas and 30 cases normal colonic mucosa.Their relationships with clinicopathological features were analyzed.Results The positive expression rate of Ezrin [...]
15
May
Expression and significance of E-cadherin and Bcl-2 in early renal carcinoma and adjacent tissues of different levels of distance
Objective To test the expression of E-candherin and Bcl-2 in early renal carcinoma and adjacent tissues,provide a theoretical basis for the safety margins in nephron sparing surgery.MethodsThe clinical data of 45 patients who were undertaken radical nephrectomy in the First Affiliated Hospital of Henan Scientific and Technological University,pathological diagnosis were all renal clear cell carcinoma.Taken [...]
15
May
EXPRESSION OF Slug AND E-cadherin AND ITS SIGNIFICANCE OF NON-SMALL-CELL LUNG CANCER
Objective To detect the expression of E-cadherin and Zinc finger transcription factors Slug in non-small-cell lung cancer(NSCLC) and metastasis in its corresponding lymph nodes,and explore the correlation between the two parameters and their association with metastasis of the cancer. Methods The expression of E-cadherin and Slug was detected by SP immunohistochemical method in 80 cases [...]
13
May
N-cadherin and E-cadherin expressions and significance before and after interventional treatment for locally advanced cervical cancer cells
Objective To investigate the expressions of adhesion molecules E-cadherin and N-cadherin before and after interventional treatment for locally advanced cervical cancer cells and and thus evaluate its effect on tumor metastasis and infiltration.Methods Immunohistochemistry(SP) was used to detect E-cadherin and N-cadherin expressions in 14 cases before and after interventional therapy in patients with locally advanced [...]
12
May
Expression of Snail and E-cadherin in Epithelial Ovarian Cancer and Their Relationship with Epithelial-Mesenchymal Transition
Objective: To investigate the expression of epithelial-mesenchymal transition(EMT) related markers Snail and E-cadherin proteins in epithelial ovarian carcinoma and their relationship with the malignant features.Methods: The expression of Snail and E-cadherin proteins was detected in 45 cases of epithelial ovarian cancer by immunohistochemistry method and its relationship with clinic pathological data was also analyzed.Results: Snail [...]
11
May
11
May
Expressions and Significances of Golgi α-Mannosidase Ⅱ and E-Cadherin in Normal Liver Tissue and Liver Cancer Tissues
Objective To investigate the expressions and significances of Golgi α-mannosidase Ⅱ(GMⅡ) and E-cadherin in normal liver tissue and liver cancer tissues.Methods The expressions of GMⅡ and E-cadherin mRNAs in normal liver tissue and in highly and lowly differentiated liver cancer tissues were determined by RT-PCR,while those of proteins by SP immunohistochemical assay and Western blot,based [...]
8
May
Expression and Correlation of TMPRSS4 and E-cadherin in Human Pancreatic Ductal Adenocarcinoma
Objective To study the expression of TMPRSS4 and E-cadherin in human pancreatic ductal adenocarcinoma and their correlation with biological behaviors of pancreatic ductal adenocarcinoma.Methods Western blot was used to detect the expressions of TMPRSS4 and E-cadherin protein in 16 samples of pancreatic ductal adenocarcinoma tissues and adjacent normal pancreatic tissues.The expression of TMPRSS4 and E-cadherin [...]