Objective To investigate the effect and mechanism of β-elemene on apoptosis in human gastric cancer MGC803 cells.Methods Human gastric cancer MGC803 cells were treated with different concentrations of β-elemene for 24～48 h,and the cell viability was measured by MTT assay,apoptosis was evaluated by flowcytometry following propidium iodide(PI) staining.Western blot was employed to detect the expression [...]
17
May
17
May
16
May
Relationship between the expression of apoptosis protein livin and the prognosis of gastric carcinoma
Gastric carcinoma belongs to an extremely malignant cancer an early diagnosis and therapy is essential to a prolonged survival of the patients.As one of inhibitive factor of IAP(Inhibitor of apoptosis protein) family,livin is expressed in most cancer patients and it becomes a hot research subject for diagnosis and therapy.In this paper the new progress in [...]
15
May
Study of the relationship between the expression of CDX2,EGFR and the biological behavior of gastric cancer
Objective To study the relationship between expression of CDX2 and EGFR in gastric cancer tissue and clinical pathology of gastric cancer.Methods Fifty cases of gastric carcinoma and the corresponding paired adjacent tissue were collected.The expression of CDX2 and EGFR was tested using immunohistochemical method,and the relationship of its expression and clinic pathological characteristics of gastric [...]
15
May
Expression and clinical significance of Survivin and Runx3 in gastric carcinoma
Objective:To study the expression and clinical significance of Survivin and Runx3 in gastric carcinoma tissue.Methods:The expressions of Survivin and Runx3 were detected by SP immunohistochemical technique in 52 cases of gastric carcinoma and analyze the relationship between the expression of Survivin,Runx3 and the clinicopathological character of samples.Results:The expression rate of Runx3 in gastric cancer was [...]
14
May
The Expression of Hes1 and Notch1 in BGC-823 Cell Line and Gastric Carcinoma
Objective To analyze the expression and their significance of Hes1 and Notch1 in gastric carcinoma.Methods The immunohistochemistry was used to detect the expression of Hes1 and Notch1 in different types of gastric adenocarcinoma tissue and BGC-823 cells.The relationship between Hes1 and Notch1 expression characteristics of gastric carcinoma and progression were analyzed.Results A few of BGC-823 [...]
13
May
A Key Regulatory Factor in Gastric Cancer—-microRNAs
MicroRNAs(miRNAs) are a class of intracellular small RNA molecules which are evolutionarily conserved and single-stranded,consisting only 19 ～25 nucleotides in length,which are involved in many cellular processes such as proliferation,differentiation and apoptosis.They are closely related to biological development and many diseases,such as cancer.In recent years,study on the gastric cancer-related miRNAs are continuously deepened.The researchers fully [...]
13
May
Research Advance of Medicinal Insects in Treatment of Gastric Carcinoma
In recent years,there have been some new progress about the medicinal insects in treatment of various tumour,especially in treatment of gastric carcinoma,scientists have discovered that there are several medicinal insects can obviously suppress growth and multiplication of the gastric carcinoma cells.Comparing to past chemotherapy drugs,medicinal insects have strong activity,anti-cancer mechanism is diversiform,fewer side effects,which has [...]
13
May
A clinical study of S-1 plus oxaliplatin (L-OHP) in the treatment of advanced gastric carcinoma
Objective To evaluate the efficacy and side effects of the combination of S-1 and Oxaliplatin(L-OHP) in patients with advanced gastric carcinoma.Methods Sixty-four patients with advanced gastic cancer were divided into treatment group and control group.The treatment group was given S-1(60 mg/d,twice daily,d1～14) combined with Oxaliplatin(130 mg/m2,ivgttd1).The control group was treated with 5-FU(750 mg/d,ivgtt d1～d5) plus [...]
12
May
Capecitabine Used for Maintenane Therapy of Adjuvant Chemotherapy after Operation of Late Gastric Cancer Patients
Objective To observe the treatment effect and adverse events of continuous maintenance with Capecitabine after postoperative adjuvant chemotherapy in advanced gastric carcinoma.Methods Totally 26 patients with advanced gastric carcinoma received oral Capecitabine after postoperative adjuvant chemotherapy till 6 months,to observe the time till progression,recurrence rate of 1 year and the adverse events.Results 6 of 26 [...]