Objective To investigate the expressions of DLK1(delta drosophila homolog-like1) and ABCG2(ATP-binding cassette superfamily G member 2)in primary human hepatocellular carcinoma(HCC).Methods The expressions of DLK1 protein and ABCG2 protein in 150 samples of HCC,50 samples of cirrhosis,50 samples of hepatitis and 10 samples of normal liver tissues were assessed by immunohistochemistry.The expressions of DLK1 mRNA and [...]
18
May
18
May
Diagnosis and treatment for gastrointestinal tract stromal tumors of small intestine
Objective To review the diagnosis,treatment and prognosis of gastrointestinal stromal tumors(GIST) of the small intestine.Methods The clinicopathological and follow-up data of 25 patients with GIST of the small intestine admitted to Cancer Hospital during March 1999 to May 2006 were analyzed retrospectively.Results The pathological examination showed malignant lesions in 23 cases(92.0%),junctional lesions in 2 cases(8.0%).The [...]
18
May
Expressions of LOX and HIF-1 protein in breast cancer tissues and their clinical significance
OBJECTIVE:To study the expression of LOX and HIF-1 protein in human breast cancer tissues and explore the relationship between LOX expression and patient’s age,tumor size,axillary node metastasis,clinical stage,HIF-1 protein expression.METHODS:The expressions of LOX and HIF-1 Protein in 56 cases of human breast cancer tissues,56 normal breast tissues and 20 cases of breast benign lesion tissues [...]
18
May
Expressions of EphA2 and EphrinA1 in breast cancer tissues and their clinical significance
OBJECTIVE:To study the protein expressions of EphA2 and EphrinA1 in breast cancer tissues and to explore their significance.METHODS:Using immunohistochemistry Sp method to detect the protein expressions of EphA2 and EphrinA1 in cancer tissues from 130 breast cancer patients.Then studying their relationship to clinicopathological factors.RESULTS:Among the 130 breast carcinoma cases,The total positive rate of EphA2 and [...]
18
May
Expressions of Survivin and Caspase-3 in Tissues of Colonic Cancer and Colonic Adenoma and their Signifi-cances
In this studv by usine immunohistochemistry stain method Survivin and Caspase-3were detected in the colonic cancer tissue and normal tissue of 42patients,and colonic adenoma tissue of 38patients so as to investigate the expressions of the two proteins and their significance.As results,the positive expression rate of Survivin in the tissue of colonic cancer was significantly higher [...]
18
May
Study of the Methods of Fluorescence in Situ Hybridization and Immunohi stochemistry in Detecting HER-2 in Colorectal Cancer
Objective:To detect HER-2 expression in colorectal cancer tissues using immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH),to analyze the significance of HER-2 expression in colorectal cancer. Methods:The expression of HER-2 protein in 68 cases of colorectal cancer and 40 cases of peri-cancer mucosa was detected by EnVision IHC.The correlations of HER-2 expression with clinicopathological parameters and prognosis [...]
18
May
Expressions of apoptosis-associated genes PDCD5 in Uygur and Han in Xinjiang in Cervix cancer and its clinical significance
Objective:To evaluate the expression and clinical signifcance of PDCD5 in Uygur and Han in Xinjiang in Cervix cancer. Methods:Using immunohistochemistry used to detect the expression of PDCD5 in 42 patients with Cervix cancer(Uygur 18 cases,24 cases of the Han). Results:There were the expressions of PDCD5 in Uygur and Han no significant difference(P>0.05). Conclusion:⑴the expressions of [...]
17
May
Expression and significance of TRAIL and its receptor in epithelial ovarian tumors
Objective To investigate the expression of TNF-related apoptosis inducing ligand(TRAIL)and its receptor in ovarian tumor and ovarian tumor.Methods Immunohistochemical method was used to detect the expressions of TRAIL and its receptor in 20 samples of ovarian tissue,22 samples of ovarian benign tumor,and 26 samples of the ovarian cancer.Results The TRAIL expression rate in normal ovarian,ovarian [...]
17
May
Expression of Bmi-1 in NSCLC and Its Relationship to Clinicopathologic Characters
Objective:To investigate the relationship between the expression of Bmi-1 in nonsmall-cell lung cancer(NSCLC) and clinicopathologic characters.Methods:Reverse transcription-PCR(RT-PCR)was applied to detect Bmi-1 mRNA in 30 of NSCLC speci-men and 20 of tumor-adjacent tissue.Immunohistochemistry was performed to detect the expression of Bmi-1 in 52 of NSCLC specimen and 30 of tumor-adjacent tissue.Results:The expression of Bmi-1mRNA in NSCLC [...]
17
May
P53 AND ERK GENE EXPRESSION IN COLONIC CARCINOMA
Objective:To investigate the expression of p53 and ERK in colonic carcinoma(CC) and their relationship tocliniocpathological factors.Methods:In 40 cases with CC,by using immunoihstochemicla technigue,the expression of p53 and ERK was detected.Results:1.The positive rate of P53 in colorectal cancer was 57.5%,associating with the loss of tumor differentiation 、lymphnode metastasis、deep invasion and dukes stage((p<0.05),but not with patients sex、age、tumor [...]