With the fast development of early diagnosis and treatment for cancers,the survival rates of victims of this deadly disease has been greatly increased.Yet the survivors still face the threat of reoccurrence.More and more evidence documented that these disease-free patients(and even some so-called healthy people) harbor dormant tumor cells,which are now regarded as the main cause [...]
18
May
Dormant tumor cells:Root for recurrence and target for therapy
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TAGS: adoptive cell therapy, dormant tumor cells, metastasis, Neoplasms, Recurrence, target for therapy
CATEGORIES: Breast Cancer
18
May
Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene
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AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction. Functional analysis of miR-622 expression was assessed in vitro in gastric cancer cell lines with miR-622 precursor and inhibitor. The roles [...]
TAGS: Gastric cancer, Inhibitor of growth family member 1, metastasis, MicroRNA, MiR-622
CATEGORIES: Prostate Cancer
17
May
Expression of miR-29 in gastric cancer and its clinicopathological significance
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Objective To explore the expression of miR-29 in gastric cancer and its relationship with clinical pathological features and prognosis.Methods The expression of miR-29 in 86 cases of gastric cancer was tested by real time PCR.Results The rate of low miR-29 expression in cases of lymph node metastases was significantly higher than those without lymph node [...]
TAGS: Gastric cancer, metastasis, microRNAs, miR-29, Prognosis
CATEGORIES: Stomach Cancer
17
May
Expression of MMP-7 and PTEN in non-small cell lung cancer and its significance
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Objective:To study the correlation between the expression of MMP-7 and PTEN with clinical pathological characteristic invasion and metastasis in an attempt to investigate their expression levels in NSCLCs and its corresponding adjacent tissue and provide the theoretical foundation for the mechanism of NSCLC and new thinking for its early diagnosis.Methods:The expression levels of MMP-7 and [...]
TAGS: Immunohistochemistry, invasion, matrix metallop roteinase-7, metastasis, non-small cell lung cancer, phosphatase and tensin homology deleted on chromosome ten
CATEGORIES: Cancer Research
16
May
Survival Analysis of 1,742 Patients with Stage Ⅳ Non-small Cell Lung Cancer
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Background and objective At present non-small cell lung cancer(NSCLC) is still the leading cause of death induced by cancer. The aim of this study is to investigate the prognostic factors of advanced NSCLC. Methods Total 1,742 cases of stage IV NSCLC data from Jan 4,2000 to Dec 25,2008 in Shanghai Chest Hospital were collected,confirmed by [...]
TAGS: Lung neoplasms, metastasis, Prognosis
CATEGORIES: Cancer Research
16
May
The dual roles of caveolin-1 in tumorigenesis and tumor development
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Caveolin-1 is a major structural protein of caveolae and plays important roles in endocytosis,cholesterol transport,signal transduction and tumorigenesis.The exact function of caveolin-1 in tumor remains controversial.Caveolin-1 acts as a tumor suppressor in breast cancer,lung cancer and ovarian cancer,but plays an opposite role in prostate cancer.This suggests that the biological function of caveolin-1 in tumor is [...]
TAGS: apoptosis, Caveolin-1, metastasis, tumor
CATEGORIES: Cervical Cancer
16
May
Expression of uPA and microvessel density correlate with invasion and metastasis of hypopharyngeal squamous cell carcinoma
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Objective To explore the difference between expressions of the urokinase-type plasminogen activator(uPA) and microvessel density(MVD) in cancer tissue and adjacent normal tissue of hypopharyngeal squamous cell carcinoma(HSCC) and to study their correlation with invasion and metastasis of HSCC.Methods Expressions of uPA and MVD of 60 patients with HSCC and 20 cases of paraneoplastic tissues were [...]
TAGS: Hypopharyngeal neoplasm, immunohisto-chemistry, invasion, metastasis, Microvessel density, Squamous cell carcinoma, Urokinase - type plasminogen activator
CATEGORIES: Liver Cancer
16
May
The Invasion in Highly Metastatic Lung Cancer Cells 95-D and Expression of Twist,Snail and Sip1 Regulated by Feiyanning Decoction
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Objective:Early in vivo experiments(article published) confirmed epithelial-mesenchymal transition of nuclear transcription factor twist and snail had important effect on Feiyanning decoction for its anti-tumor metastasis role.This in vitro study is to further explore Feiyanning’s influence on highly metastatic lung cancer 95-D cells migration and twist,snail and Sip1 gene and protein expression based on previous research.Methods:Feiyanning [...]
TAGS: epithelial - mesenchymal transition, lung cancer, metastasis, SIP1, Snail, tradition Chinese medicine, Twist
CATEGORIES: Skin Cancer
16
May
Effect of survivin siRNA on the invasive capacity of ovarian carcinoma cells
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Objective: To investigate the effects of RNA interference(RNAi) targeting survivin gene on the invasive capacity of SKOV3 cells.Methods: Template sequence for survivin siRNA was designed and synthesized.Lipofectamine 2000 mediated transient transfection was conducted to transmit the siRNA into SKOV3 cells.The survivin gene expression was assessed by Western blot assays.Changes of invasive capacity of SKOV3 cells [...]
TAGS: metastasis, Ovarian carcinoma, RNAi, SKOV3 cells, Survivin gene
CATEGORIES: Skin Cancer
16
May
Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer
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Objective To explore the relationship between hypoxia-inducible factor-1α(HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.Methods HIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.Results Seventeen patients with colorectal cancer showed positivity for HIF-1α mRNA,showing a significantly higher positivity rate(42.5%) [...]
TAGS: colorectal cancer, Hypoxia inducible factor-1α, metastasis
CATEGORIES: Prostate Cancer
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