Objective To observe the expression and its clinical significance of P53,CD44 and EGFR in non-small cell lung cancer(NSCLC).Methods Expression of P53,CD44 and EGFR was detected by immunohistochemistry in 87 NSCLC tissues,and their relationship was analyzed.Results The positive rate of P53,CD44 and EGFR was 49.4%,60.9% and 67.8%,respectively,in NSCLC tissues.The positive rate of P53 with stage III-IV [...]
18
May
17
May
Expression of EGFR in Tissues of Non-small Cell Lung Cancer in Guangxi
Objective To investigate the expression of epidermal growth factor receptor(EGFR)in non-small cell lung cancer(NSCLC)tissue and its relation with clinical pathology and nationality.Methods The expressions of EGFR in 76 lung cancer samples,23 adjacent samples and 8 non-lung cancer samples were detect by real-time PCR.Results The expression of EGFR in lung cancer samples was higher than that [...]
17
May
Clinical Effects of Double-way Chemotherapy on Non-small Cell Lung Cancer with Malignant Pericardial Effusion
Objective To investigate the effect of double-way chemotherapy on non-small cell lung cancer with malignant pericardial effusion.Method We selected 42 cases of confirmed non-small cell lung cancer with malignant pericardial effusion by cytological and / or histological examination.All 42 patients underwent pericardial cavity closed drainage,and were randomly divided into A group and B group(21 patients [...]
17
May
17
May
Study of correlation between TGF-β1,TNF-α and IL-6 levels in plasma and radiation pneumonitis in patients with non-small-cell lung cancer
Objective To correlate the transforming growth factor-β(TGF-β1),tumor necrosis factor(TNF-α),interleukin-6(IL-6)levels in non-small-cell lung cancer(NSCLC)patients during radiation therapy(RT)with the occurrence of radiation pneumonitis(RP).Methods Thirty-seven NSCLC patients who received three-dimensional conformal radiation therapy were evaluated prospectively.Serial blood samples before,in the middle of,at the end of RT and 2 and 4 weeks after RT were analyzed for cytokine by [...]
17
May
Serum CEA level is associated with efficacy and prognosis of EGFR-TKI treatment in non-small cell lung cancer:report of 88 cases
Objective To identify the correlation of the serum carcinoembryonic antigen(CEA) level and the therapeutic effect of epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI) as a gene targeted drug in advanced non-small cell lung cancer(NSCLC).Methods We retrospectively reviewed 88 NSCLC patients,including 69 adenocarcinoma and 19 non-adenocarcinoma who admitted in our hospitals from July 2007 to November [...]
17
May
Observation on the clinical effect of combined therapy of GP regimen plus Aidi injection on advanced stage non-small-cell lung cancer
【Objective】 To observe and evaluate the clinical effects for Combinaed therapy of GP regimen plus Aidi injection on advanced stage non-small lung cancer.【Methods】 52 patients were enrolled in the study and divided into two groups(GP-plus-Aidi group and GP group) randomly,and the GP group was used as a control.The patients in GP-plus-Aidi group were given Gemcitabine [...]
17
May
17
May
A study on the relationship between expression of KI-67,PCNA and metastasis and prognosis in patients with non-small cell lung carcinoma
Objective To study the relationship between expression of Ki-67,PCNA and metastasis and prognosis in patients with non-small cell lung cancer.Methods The expression of Ki-67 and PCNA were examined with immunohistochemical technique in 128 specimens of NSCLC and 32 normal neighboring lung tissues.Results The expression of Ki-67 and PCNA in NSCLC tissues was significantly higher than [...]
17
May
Preclinical progress in targeted therapies for non-small cell lung cancer
Targeted therapies against the epidermal growth factor receptor(EGFR) and angiogenesis pathways for advanced non-small cell lung cancer(NSCLC) have been successful,but the survival for most patients remains modest due to resistance to EGFR inhibitors.Secondary EGFR T790M mutation and amplification of MET oncogene were identified as two principal mechanisms of drug resistance.TGF-β/IL-6 axis was reported to mediate [...]