Objective To explore the expression of survivin and p53 in epithelial ovarian cancer and their clinical significances.Methods Expression intensity of survivin and p53 were detected by immunohistochemistry in the tissues of 46 cases with epithelial ovarian cancer,the relationship between clinical and pathological characteristics with survivin and p53 expressions were analysed.The 44 cases with benign epithelial [...]
17
May
17
May
17
May
miR-146a gene polymorphism and the risk of ovarian cancer:a case-control study
Objective:To investigate the association between the miR-146a gene polymorphism(rs2910164) and the susceptibility of ovarian cancer in Jiangsu province.Methods:In a hospital-based case-control study of 131 patients with newly diagnosed ovarian cancer and 221 cancer-free controls frequency-matched by age,the polymorphism of miR-146a gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).The risk of ovarian cancer was [...]
17
May
Expression of Mitogen Activated Protein Kinase p38 and Hypoxia-inducible Factor 1α in Epithelial Ovarian Cancer
Objective To investigate the expression and correlation of p38 and HIF-1α in ovarian cancer tissue. Methods The expression of p38 and HIF-1α were assessed by immunohistochemical staining in 60 cases of ovarian cancer, 21 cases of carcinoma in situ, 30 cases of ovarian benign neoplasm of ovary and 30 cases of normal ovarian tissue. Results [...]
16
May
16
May
Cisplatin-resistance increases proliferation,invasion and migration of ovarian cancer OVCAR-3 cells
Objective: To investigate the differences in biological behavior between cisplatin-sensitive(OVCAR-3 cells) and cisplatin-resistant human ovarian cancer cells(OVCAR-3/CDDP cells),and to explore the possible mechanisms.Methods: OVCAR-3 and OVCAR-3/CDDP cells in logarithmic phase were collected,their proliferation were assessed by soft agar colony formation assay,their in vitro and in vivo invasion and migration abilities were measured by Transwell chamber [...]
16
May
Expressions and significances of Livin,Smac and Ki67 in epithelial ovarian carcinoma
Objective:To explore the expressions and significances of inhibitor of apoptosis protein-Livin,apoptosis related factor-Smac and proliferating cell nuclear antigen-Ki67 in epithelial ovarian carcinoma,and analyze their correlation.Methods:Immunohistochemical SP method was used to detect the expression levels of Livin,Smac and Ki67 in 50 cases with epithelial ovarian cancer,20 cases with borderline ovarian tumor,20 cases with benign ovarian tumor [...]
16
May
Effect of Chinese herbal compound drug serum on the expressions of BID and CTNNB1 gene in human ovarian cancer cell line SKOV3
Objective:To study the effects of BID and CTNNB1 gene on apoptosis of human ovarian cancer cell line SKOV3 induced by Chinese herbal compound Lichongshengsui drink.Methods:Wistar rats were divided into two group at random and treated with pouring Lichongshengsui drink into stomach,blood samples were obtained to prepare Chinese herbal compound drug serum.mRNA of tumor cells in [...]
14
May
Postmenopausal hormone therapy and ovarian cancer
Hormone therapy(HT) offers well-established clinical benefits,such as relief of menopausal symptoms,prevention of menopausal osteoporosis,improving the quality of menopause women’s life.However,Information regarding the impact of HT on risk of ovarian cancer is relatively controversial.Whether HT increases the risk of ovarian cancer? Whether ovarian cancer patients who underwent HT would suffer from the increasing risk of recurrence? [...]
14
May
Expressions of Lewis y Antigen and α1,2-fucose Transferase Gene in Ovarian Cancer Cell Line
Objective To study the expressions of Lewis y antigen and α1,2-fucose transferase(α1,2-fucosyltransferases,α1,2-FT) gene FUT1 in ovarian cancer cell lines and their influences on proliferation,drug resistance and metastasis of ovarian cancer cells.Methods The immuocytochemical method and immunocyto-fluorescence methold were used to detect the expression of Lewis y antigen in RMG-I-H and RMG-I,highly metastatic human ovarian cancer [...]