Objective To observe the expression and its clinical significance of P53,CD44 and EGFR in non-small cell lung cancer(NSCLC).Methods Expression of P53,CD44 and EGFR was detected by immunohistochemistry in 87 NSCLC tissues,and their relationship was analyzed.Results The positive rate of P53,CD44 and EGFR was 49.4%,60.9% and 67.8%,respectively,in NSCLC tissues.The positive rate of P53 with stage III-IV [...]
18
May
18
May
The Expression and Correlation Studies of HPV16/18 Infection and p53 in Female with Breast Infiltrating Ductal Carcinoma
Objective To explore the expression and their relationship of HPV16/18 infection and p53 in female with breast infiltrating ductal carcinoma.Methods The expression level of HPV16/18 DNA and p53 in women breast infiltrating ductal carcinoma(n=45),breast fibroadenoma(n=20) and normal breast tissue(n=20) were detected with immunohistochemistry methods and PCR technology,respectively.Results HPV16/18 DNA and p53 protein expression rate in [...]
17
May
Study on expressions of survivin and p53 in epithelial ovarian cancer
Objective To explore the expression of survivin and p53 in epithelial ovarian cancer and their clinical significances.Methods Expression intensity of survivin and p53 were detected by immunohistochemistry in the tissues of 46 cases with epithelial ovarian cancer,the relationship between clinical and pathological characteristics with survivin and p53 expressions were analysed.The 44 cases with benign epithelial [...]
17
May
P53 AND ERK GENE EXPRESSION IN COLONIC CARCINOMA
Objective:To investigate the expression of p53 and ERK in colonic carcinoma(CC) and their relationship tocliniocpathological factors.Methods:In 40 cases with CC,by using immunoihstochemicla technigue,the expression of p53 and ERK was detected.Results:1.The positive rate of P53 in colorectal cancer was 57.5%,associating with the loss of tumor differentiation 、lymphnode metastasis、deep invasion and dukes stage((p<0.05),but not with patients sex、age、tumor [...]
17
May
Xanthogranulomatous cholecystitis:a premalignant condition?
BACKGROUND:Xanthogranulomatous cholecystitis(XGC)is an uncommon variant of chronic cholecystitis,characterized by marked thickening of the gallbladder wall and dense local adhesions.It often mimics a gallbladder carcinoma(GBC), and may coexist with GBC,leading to a diagnostic dilemma. Furthermore,the premalignant nature of this entity is not known.This study was undertaken to assess the p53,PCNA and beta-catenin expression in XGC in [...]
16
May
The Relationship Between HPV18E6 Infection,the Expression of PCNA,p53 and Cervix Squamous-celled Carcinoma
Objective The correlation between cervical cancer and the expression of human papillomaviral infection,proliferating cell nuclear antigen and p53 was investigated in our study.Methods The expression of HPV18E6,PCNA and p53 were examined in these forty-two paraffin blocks undertaken immunohistochemical treatment.Results The expression rate of HPV18E6 in the patients of cervix squamous-celled carcinoma is 73.81%.The expression rate [...]
16
May
Effects of Neoadjuvant Chemotherapy on ER,P53 and HER-2 Expression in Breast Cancer
Objective To explore the expressions of estrogen receptor(ER),P53 gene and human epidermal growth factor receptor(HER-2) in breast cancer tissues treated by neoadjuvant chemotherapy and their clinical significance.Methods Expressions of ER,P53 and HER-2 were determined by immunohistochemistry in 100 breast cancer(BC) patients before and after neoadjuvant chemotherapy and their relationship to the effect.Results The overall response [...]
15
May
SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer
AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, [...]
15
May
Danshensu-induced Apoptosis in Human Hepatocellular Carcinoma Cell Line SMMC7721
Background: Danshensu is extracted from the dry root of Chinese herb medicine Salvia miltiorrhiza Bge.It has antioxidant properties and cytotoxic activity against many human cancers.Aims: To investigate apoptotic effect of Danshensu on human hepatocellular carcinoma cell line SMMC7721 in vitro and to elucidate its mechanism.Methods: Hepatocellular carcinoma cell line SMMC7721 was incubated with different concentrations [...]
15
May
Inhibition mechanism of Vitamin E succinate on coexpression of Her-2 and p53 in breast cancer cell
Objective:To investigate the effects of VES inducing human breast cancer cell line MDA-MB-453 apoptosis,changes of the expression of Her-2 and p53 before and after apoptosis and changes of the mRNA of Her-2 gene.Methods:MTT assay was used to detect MDA-MB-453 cell proliferation.Cell cycle and apoptosis were analyzed by flow cytometry.The level of Her-2 mRNA was detected [...]